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The purpose of this paper is to assess nurse’s knowledge and practice regarding basic life support (BLS) skills while working with SARS-CoV-2 patients in Jordanian hospitals.

A cross-sectional survey was conducted among 386 nurses with direct contact with SARS-CoV-2 patients at Jordanian hospitals. A self-administered structured questionnaire was used based on the American Heart Association (AHA) guidelines.

A total of 386 participants were recruited. The mean years of experience were 7.89 (SD = 5.97). About three quarters of participants revealed they deal with SARS-CoV-2 patients directly (n = 284, 73.6%). The total mean score of nurse’s knowledge was 4.44 (SD = 1.22), while the total mean score of practice was 8.44 (SD = 2.05). Independent t-test was used, which revealed a statistically significant difference between educational level and total score of nurse’s knowledge [t(386) = 0.215 and p = 0.001] and between training to deal with SARS-CoV-2 during BLS and total score of practice [t(386) = 2.66 and p = 0.008]. Pearson correlation discloses a positive correlation between the total score of knowledge and practice (r = 0.343 and p = 0.001).

In general, nurses revealed a moderate level of knowledge and practice of BLS skills. However, assessing nurse’s knowledge and practice during the outbreak of SARS-CoV-2 plays a key role in identifying the gap in nurse’s knowledge and practice, and therefore, it will have an impact on providing high-quality BLS to save infected patients while providing maximum safety according to AHA guidelines.

This study is the first study that examined the level of knowledge and practice of BLS skills during SARS-CoV-2 pandemic in Jordan.